Using Magnetic Resonance Imaging (MRI) to obtain shapes and sizes of Pinniped and Cetacean brain regions that depend on thyroid hormones for maturation
Title | Using Magnetic Resonance Imaging (MRI) to obtain shapes and sizes of Pinniped and Cetacean brain regions that depend on thyroid hormones for maturation |
Publication Type | Conference Paper |
Year of Publication | 2004 |
Authors | Montie, E. W., M. Moore, D. R. Ketten, J. J. Arruda, A. Bogomolni, and M. Hahn |
Conference Name | EPA STAR Graduate Fellowship Conference |
Keywords | cetaceans, hormones, magnetic resonance imaging, marine mammals, maturation, MRI, pinnipeds, thyroid |
Abstract | Thyroid hormones (TH) play an integral role in neuro-development, particularly in the maturation of the corpus callosum, cerebellum, hippocampus, and inner ear (1). In rodents, persistent organic pollutants (POPs), particularly polychlorinated biphenyls (PCBs), interfere with TH signaling (2). These pollutants are widespread in the marine environment and biomagnify in marine mammals to very high levels (3). Brominated flameretardants (BFRs) have also recently been shown to interfere with the TH system in experimental animals (4). Although at the present time BFR levels are much lower than PCBs, BFRs have been shown to biomagnify in marine mammals (5). Hence, there is concern that PCBs and BFRs with similar mechanisms of toxicity may affect neuro-development of marine mammals. |
- brain
- brain regions
- Centre for Magnetic Resonance Investigations
- cetacean
- cetaceans
- hormones
- Imaging
- magnetic resonance imaging
- marine mammals
- maturation
- medical imaging
- Medical physics
- MRI
- pinniped
- pinnipeds
- radiology
- resonance
- shapes and sizes
- Technology Internet
- thyroid
- thyroid hormone
- thyroid hormones
- using magnetic resonance imaging
- Whole-body nuclear scanning